Absence of linkage between human obesity and the mouse agouti homologous region (20q11.2) or other markers spanning chromosome 20q.

doi:10.1002/j.1550-8528.1995.tb00190.x

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Article

Absence of linkage between human obesity and the mouse agouti homologous region (20q11.2) or other markers spanning chromosome 20q.

Obesity research - 1 Nov 1995

Xu W, Reed D R, Ding Y, Price R A

Abstract excerpt

Mutant alleles of the agouti gene cause obesity in the mouse and the homologous gene in humans has been mapped to chromosome 20q11.2. An allelic variant of the agouti gene could account for obesity in humans and we tested this hypothesis by genotyping 210 sibling pairs from 45 families segregatin...

Topics

Age of Onset
Alleles
Animals
Body Mass Index
Chromosomes, Human, Pair 20
Female
Genetic Linkage
Genotype
Humans
Male
Mice
Mutation
Obesity
Phenotype
Sequence Homology, Amino Acid

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