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Article

Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jun 1996

Hartzog G A, Basrai M A, Ricupero-Hovasse S L, Hieter P, Winston F

Abstract excerpt

Spt4p is a nonhistone protein of Saccharomyces cerevisiae that is believed to be required for normal chromatin structure and transcription. In this work we describe the isolation and analysis of a human gene, SUPT4H, that encodes a predicted protein 42% identical to Spt4p. When expressed in S. cerevisiae, SUPT4H complemented all spt4 mutant phenotypes. In human cells SUPT4H encodes a nuclear protein that is...

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Identifiers

PMID: 8649394
DOI: 10.1128/MCB.16.6.2848
PMCID: PMC231277

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