Article
Molecular analysis of scabrous mutant alleles from Drosophila melanogaster indicates a secreted protein with two functional domains.
Genetics - 1 Oct 1995
Hu X, Lee E C, Baker N E
Abstract excerpt
Mutations at the scabrous locus (sca) affect cell-cell signaling during neural development. Twenty-one mutant alleles of scabrous have been analyzed. Many synthesize no sca protein. In others, a defective protein is arrested intracellularly. Two mutants in which protein is not arrested must affec...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Transposable Elements
- Drosophila Proteins
- Drosophila melanogaster
- Ethyl Methanesulfonate
- Gene Expression
- Genes, Insect
- Genotype
- Glycoproteins
- Immunohistochemistry
- Molecular Sequence Data
- Mutagenesis
- Mutagenesis, Insertional
- Protein Biosynthesis