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Article

Single amino acid mutations in Drosophila fascin disrupt actin bundling function in vivo.

Genetics - 1 May 1996

Cant K, Cooley L

Abstract excerpt

Fascins bundle actin filaments into large, tightly packed hexagonal arrays that support diverse cellular processes including microvillar projections and filopodial extensions. In Drosophila, fascin is encoded by the singed locus. Severe singed mutants have gnarled bristles and are female sterile...

Topics

Actins
Alleles
Amino Acid Sequence
Animals
Carrier Proteins
Crosses, Genetic
Cytoplasm
Drosophila melanogaster
Ethyl Methanesulfonate
Female
Genes, Insect
Male
Microfilament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis

Point Mutation

Recombinant Proteins

Sea Urchins

Source

Open in PubMed Open full text

Identifiers

PMID: 8722779
DOI: 10.1093/genetics/143.1.249
PMCID: PMC1207258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8722779-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Single amino acid mutations in Drosophila fascin disrupt actin bundling function in vivo.PMID 8722779Read ↗

Fascin promotes filopodia formation independent of its role in actin bundlingSemantic proximity Read ↗

Drosophila singed, a fascin homolog, is required for actin bundle formation during oogenesis and bristle extension.Semantic proximity Read ↗

Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architectureSemantic proximity Read ↗

Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling.Semantic proximity Read ↗

Drosophila fascin mutants are rescued by overexpression of the villin-like protein, quail.Semantic proximity Read ↗

Fascin is required for blood cell migration during Drosophila embryogenesis.Semantic proximity Read ↗

Novel fold revealed by the structure of a FAS1 domain pair from the insect cell adhesion molecule fasciclin I.Semantic proximity Read ↗

Midline Fasciclin: a Drosophila Fasciclin-I-related membrane protein localized to the CNS midline cells and trachea.Semantic proximity Read ↗

Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila.Semantic proximity Read ↗

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The gene for the intermediate chain subunit of cytoplasmic dynein is essential in Drosophila.Semantic proximity Read ↗

A structure-function analysis of NOD, a kinesin-like protein from Drosophila melanogaster.Semantic proximity Read ↗

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