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Article

Substrate selection by aminoacyl-tRNA synthetases.

Nucleic acids symposium series - 1 Jan 1995

Ibba M, Thomann H U, Hong K W, Sherman J M, Weygand-Durasevic I, Sever S, Stange-Thomann N, Praetorius M, Söll D

Abstract excerpt

The integration of genetic and biochemical approaches to study the crystal structure of the glutaminyl-tRNA synthetase (GlnRS):tRNA(Gln):ATP complex has elucidated the mechanism by which GlnRS selects its cognate tRNA for aminoacylation. Three principal types of interaction have been identified: interaction with specific bases in the cognate tRNA, rejection of non-cognate tRNAs, and activation of the active site...

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PMID: 8643392

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