Article
Substrate selection by aminoacyl-tRNA synthetases.
Nucleic acids symposium series - 1 Jan 1995
Ibba M, Thomann H U, Hong K W, Sherman J M, Weygand-Durasevic I, Sever S, Stange-Thomann N, Praetorius M, Söll D
Abstract excerpt
The integration of genetic and biochemical approaches to study the crystal structure of the glutaminyl-tRNA synthetase (GlnRS):tRNA(Gln):ATP complex has elucidated the mechanism by which GlnRS selects its cognate tRNA for aminoacylation. Three principal types of interaction have been identified:...
Topics
- Amino Acyl-tRNA Synthetases
- Binding Sites
- Escherichia coli
- Geobacillus stearothermophilus
- Glutamate-tRNA Ligase
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- Protein Conformation
- RNA, Transfer, Gln
- Substrate Specificity
- Tryptophan-tRNA Ligase