Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of IGF‐IR increases chemosensitivity in human colorectal cancer cells through MRP‐2 promoter suppression

24 Jan 2012

Abstract excerpt

The emergence of multidrug resistance (MDR) in cancer cells has made many of the currently available chemotherapeutic agents ineffective. However, the mechanism involved in mediating this effect is not yet fully understood. Here, we found the overexpression of type I insulin-like growth factor receptor (IGF-IR) in established colorectal MDR cells. Specific siRNA of IGF-IR decreases cell proliferation, exert...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Estrogen and related hormone effects
Share to Growth Hormone and Insulin-like Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22275271
DOI: 10.1002/jcb.24080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of IGF‐IR increases chemosensitivity in human colorectal cancer cells through MRP‐2 promoter suppressionPMID 22275271Read ↗

Function of insulin‑like growth factor 1 receptor in cancer resistance to chemotherapy (Review)Semantic proximity Read ↗

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapySemantic proximity Read ↗

Insulin-Like Growth Factor 2 mRNA-Binding Protein 1 (IGF2BP1) Is a Prognostic Biomarker and Associated with Chemotherapy Responsiveness in Colorectal CancerSemantic proximity Read ↗

Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and ChemoresistanceSemantic proximity Read ↗

Strategies for overcoming ABC transporter-mediated multidrug resistance in colorectal cancerSemantic proximity Read ↗

Insulin-like Growth Factor I Receptor: A Novel Target for Hepatocellular Carcinoma Gene TherapySemantic proximity Read ↗

Combined Inhibition of Insulin Growth Factor 1 Receptor and Autophagy impede Colorectal Cancer MetastasisSemantic proximity Read ↗

Melatonin Increases the Anticancer Potential of Doxorubicin in Caco-2 Colorectal Cancer CellsSemantic proximity Read ↗

The receptor for the type I insulin-like growth factor and its ligands regulate multiple cellular functions that impact on metastasis.Semantic proximity Read ↗

The Insulin-like Growth Factor System and Colorectal CancerSemantic proximity Read ↗

miR-92b-3p Regulates Cell Cycle and Apoptosis by Targeting CDKN1C, Thereby Affecting the Sensitivity of Colorectal Cancer Cells to Chemotherapeutic DrugsSemantic proximity Read ↗

Regulation of multidrug resistance by microRNAs in anti-cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.