Article
A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18.
The Journal of clinical investigation - 1 Mar 1996
Willison H J, O'Hanlon G M, Paterson G, Veitch J, Wilson G, Roberts M, Tang T, Vincent A
Abstract excerpt
IgM paraproteins associated with autoimmune peripheral neuropathy and anti-Pr cold agglutinins react with sialic acid epitopes present on disialylated gangliosides including GD1b, GT1b, GQ1b, and GD3. A causal relationship between the paraprotein and the neuropathy has never been proven experimen...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Autoantibodies
- Base Sequence
- Carbohydrate Sequence
- Gangliosides
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Immunoglobulin Variable Region
- Mice
- Molecular Sequence Data