Article
A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18.
The Journal of clinical investigation - 1 Mar 1996
Willison H J, O'Hanlon G M, Paterson G, Veitch J, Wilson G, Roberts M, Tang T, Vincent A
Abstract excerpt
IgM paraproteins associated with autoimmune peripheral neuropathy and anti-Pr cold agglutinins react with sialic acid epitopes present on disialylated gangliosides including GD1b, GT1b, GQ1b, and GD3. A causal relationship between the paraprotein and the neuropathy has never been proven experimentally. From peripheral blood B cells of an affected patient, we have cloned a human hybridoma secreting an...
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