Article
Analysis of anti-GM1 ganglioside IgM antibodies cloned from motor neuropathy patients demonstrates diverse V region gene usage with extensive somatic mutation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1995
Paterson G, Wilson G, Kennedy P G, Willison H J
Abstract excerpt
Serum anti-GM1 ganglioside Abs are abnormally elevated in patients with chronic motor neuropathies and Guillain-Barré syndrome. We have cloned six anti-GM1 IgM Abs from PBMCs of five affected patients. VH and VL gene analysis demonstrated substantial somatic mutation, predominantly clustered arou...
Topics
- Amino Acid Sequence
- Autoantibodies
- Base Sequence
- Cloning, Molecular
- G(M1) Ganglioside
- Humans
- Immunoglobulin M
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation
- Polyradiculoneuropathy