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Article

Human autoantibodies specific for the α <sub>1A</sub> calcium channel subunit reduce both P-type and Q-type calcium currents in cerebellar neurons

7 Jul 1998

Abstract excerpt

The pharmacological properties of voltage-dependent calcium channel (VDCC) subtypes appear mainly to be determined by the alpha1 pore-forming subunit but, whether P-and Q-type VDCCs are encoded by the same alpha1 gene presently is unresolved. To investigate this, we used IgG antibodies to presynaptic VDCCs at motor nerve terminals that underlie muscle weakness in the autoimmune Lambert-Eaton myasthenic syndrome...

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PMID: 9653186
DOI: 10.1073/pnas.95.14.8328

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