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Article

Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function.

FEBS letters - 13 May 1996

Faerman C, Ripoll D, Bon S, Le Feuvre Y, Morel N, Massoulié J, Sussman J L, Silman I

Abstract excerpt

The location of the active site of the rapid enzyme, acetylcholinesterase, near the bottom of a deep and narrow gorge indicates that alternative routes may exist for traffic of substrate, products or solute into and out of the gorge. Molecular dynamics suggest the existence of a shutter-like back door near Trp84, a key- residue in the binding site for acetylcholine, in the Torpedo californica enzyme. The homology...

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Source

Identifiers

PMID: 8635606
DOI: 10.1016/0014-5793(96)00374-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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