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Article

Mutagenesis of essential functional residues in acetylcholinesterase.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990

Gibney G, Camp S, Dionne M, MacPhee-Quigley K, Taylor P

Abstract excerpt

The cholinesterases are serine hydrolases that show no global similarities in sequence with either the trypsin or the subtilisin family of serine proteases. The cholinesterase superfamily includes several esterases with distinct functions and other proteins devoid of the catalytic serine and known esterase activity. To identify the residues involved in catalysis and conferring specificity on the enzyme, we have...

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Identifiers

PMID: 2217185
DOI: 10.1073/pnas.87.19.7546
PMCID: PMC54784

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