Article
Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3.
Human molecular genetics - 1 Dec 1995
Cruts M, Backhovens H, Wang S Y, Van Gassen G, Theuns J, De Jonghe C D, Wehnert A, De Voecht J, De Winter G, Cras P
Abstract excerpt
Genetic linkage studies have indicated that chromosome 14q24.3 harbours a major locus for early-onset (onset age <65 years) Alzheimer's disease (AD3). Positional cloning efforts have identified a novel gene S182 or presenilin 1 as the AD3 gene. We have mapped S182 in the AD3 candidate region between D14S277 and D14S284 defined by genetic linkage studies in the two chromosome 14 linked, early-onset AD families...
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