Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases.

doi:10.1016/0304-3940(95)12170-6

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Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases.

Neuroscience letters - 8 Dec 1995

Tsuda T, Chi H, Liang Y, Rogaeva E A, Sherrington R, Levesque G, Ikeda M, Rogaev E I, Pollen D, Freedman M

Abstract excerpt

The possibility of an interaction of multiple genes has been speculated in pathogenesis of Alzheimer's disease (AD). Because we have recently cloned a novel gene S182 bearing five different missense mutations which segregate with early-onset familial AD, we sought the frequency of these mutations in familial and sporadic late-onset AD to clarify the incidence of these mutations in the disease. The current study...

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Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases.

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