Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases.

doi:10.1016/0304-3940(95)12170-6

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Article

Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases.

Neuroscience letters - 8 Dec 1995

Tsuda T, Chi H, Liang Y, Rogaeva E A, Sherrington R, Levesque G, Ikeda M, Rogaev E I, Pollen D, Freedman M

Abstract excerpt

The possibility of an interaction of multiple genes has been speculated in pathogenesis of Alzheimer's disease (AD). Because we have recently cloned a novel gene S182 bearing five different missense mutations which segregate with early-onset familial AD, we sought the frequency of these mutations...

Topics

Aged
Alzheimer Disease
Base Sequence
Cloning, Molecular
DNA Primers
Genes
Humans
Membrane Proteins
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Presenilin-1

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