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Article

Mutation analysis of the chromosome 14q24.3 dihydrolipoyl succinyltransferase (DLST) gene in patients with early-onset Alzheimer disease.

Neuroscience letters - 13 Oct 1995

Cruts M, Backhovens H, Van Gassen G, Theuns J, Wang S Y, Wehnert A, van Duijn C M, Karlsson T, Hofman A, Adolfsson R

Abstract excerpt

Linkage analysis studies have indicated that the chromosome band 14q24.3 harbours a major gene for familial early-onset Alzheimer's disease (AD). Recently we localized the chromosome 14 AD gene (AD3) in the 6.4 cM interval between the markers D14S289 and D14S61. We mapped the gene encoding dihydrolipoyl succinyltransferase (DLST), the E2k component of human alpha-ketoglutarate dehydrogenase complex (KGDHC), in...

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Source

Identifiers

PMID: 8584231
DOI: 10.1016/0304-3940(95)11982-3

Genes

DLST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis of the chromosome 14q24.3 dihydrolipoyl succinyltransferase (DLST) gene in patients with early-onset Alzheimer disease.PMID 8584231Read ↗

Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population.Semantic proximity Read ↗

Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3.Semantic proximity Read ↗

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.Semantic proximity Read ↗

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.Semantic proximity Read ↗

[Association between DLST gene polymorphism and Alzheimer's disease].Semantic proximity Read ↗

Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients.Semantic proximity Read ↗

Association between the gene encoding the E2 subunit of the alpha-ketoglutarate dehydrogenase complex and Parkinson's disease.Semantic proximity Read ↗

A DLST genotype associated with reduced risk for Alzheimer's disease.Semantic proximity Read ↗

No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome.Semantic proximity Read ↗

Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population.Semantic proximity Read ↗

A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency.Semantic proximity Read ↗

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14Semantic proximity Read ↗

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