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Article

Disruption of the yeast ATH1 gene confers better survival after dehydration, freezing, and ethanol shock: potential commercial applications.

Applied and environmental microbiology - 1 May 1996

Kim J, Alizadeh P, Harding T, Hefner-Gravink A, Klionsky D J

Abstract excerpt

The accumulation of trehalose is a critical determinant of stress resistance in the yeast Saccharomyces cerevisiae. We have constructed a yeast strain in which the activity of the trehalose-hydrolyzing enzyme, acid trehalase (ATH), has been abolished. Loss of ATH activity was accomplished by disrupting the ATH1 gene, which is essential for ATH activity. The delta ath1 strain accumulated greater levels of cellular...

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Identifiers

PMID: 8633854
DOI: 10.1128/aem.62.5.1563-1569.1996
PMCID: PMC167930

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Disruption of the yeast ATH1 gene confers better survival after dehydration, freezing, and ethanol shock: potential commercial applications.PMID 8633854Read ↗

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