Article
New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.
Applied and environmental microbiology - 1 Feb 2008
Jules Matthieu, Beltran Gemma, François Jean, Parrou Jean Luc
Abstract excerpt
In the yeast Saccharomyces cerevisiae, the synthesis of endogenous trehalose is catalyzed by a trehalose synthase complex, TPS, and its hydrolysis relies on a cytosolic/neutral trehalase encoded by NTH1. In this work, we showed that NTH2, a paralog of NTH1, encodes a functional trehalase that is implicated in trehalose mobilization. Yeast is also endowed with an acid trehalase encoded by ATH1 and an H+/trehalose...
Topics
- Culture Media
- Cytosol
- Glucosyltransferases
- Glycogen
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Trehalase
- Trehalose