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Article

IIA(Glc) allosteric control of Escherichia coli glycerol kinase: binding site cooperative transitions and cation-promoted association by Zinc(II).

Biochemistry - 27 Nov 2001

Holtman C K, Pawlyk A C, Meadow N, Roseman S, Pettigrew D W

Abstract excerpt

The catalytic activity of glycerol kinase (EC 2.7.1.30, ATP:glycerol 3-phosphotransferase) from Escherichia coli is inhibited allosterically by IIA(Glc) (previously known as III(Glc)), the glucose-specific phosphocarrier protein of the phosphoenolpyruvate:glycose phosphotransferase system. A sequentially contiguous portion of glycerol kinase undergoes an induced fit conformational change involving coil,...

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PMID: 11714284
DOI: 10.1021/bi011590w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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