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Article

Gene expression profile associated with oncogenic ras-induced senescence, cell death, and transforming properties in human cells.

Cancer investigation - 1 Jul 2010

Moumtzi Sophy S, Roberts Michael L, Joyce Tobias, Evangelidou Maria, Probert Lesley, Frillingos Stathis, Fotsis Theodore, Pintzas Alexander

Abstract excerpt

We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle genes like c-fos, cyclin E, cdk2, cell-cell contact, and signaling like integrin a6, MEK5, and free...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19883200
DOI: 10.3109/07357900903095623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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