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Article

Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.

Molecular and cellular biology - 1 May 1996

Fan Q Q, Petes T D

Abstract excerpt

Meiotic double-strand DNA breaks (DSBs), the lesions that initiate meiotic recombination at the HIS4 recombination hot spot, occur in a region upstream of the coding sequence associated with multiple DNase I-hypersensitive sites. Mutations in transcription factors that lead to loss of the DSBs result in the loss of some but not all DNase I-hypersensitive sites in the upstream region. A meiosis-specific change in...

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Source

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Identifiers

PMID: 8628269
DOI: 10.1128/MCB.16.5.2037
PMCID: PMC231190

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Source receipt: pubmed, retrieved 7 Sept 2026.

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