Article
Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.
Molecular and cellular biology - 1 May 1996
Fan Q Q, Petes T D
Abstract excerpt
Meiotic double-strand DNA breaks (DSBs), the lesions that initiate meiotic recombination at the HIS4 recombination hot spot, occur in a region upstream of the coding sequence associated with multiple DNase I-hypersensitive sites. Mutations in transcription factors that lead to loss of the DSBs re...
Topics
- Alcohol Oxidoreductases
- Aminohydrolases
- Chromatin
- DNA, Fungal
- Deoxyribonuclease I
- Fungal Proteins
- Genotype
- Meiosis
- Mitosis
- Multienzyme Complexes
- Promoter Regions, Genetic
- Pyrophosphatases
- Recombination, Genetic
- Restriction Mapping
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors