Article
A heteromeric protein that binds to a meiotic homologous recombination hot spot: correlation of binding and hot spot activity.
Genes & development - 15 Jul 1994
Wahls W P, Smith G R
Abstract excerpt
Homologous recombination hot spots are DNA sites that increase the frequency of recombination in their vicinity. The M26 allele of the ade6 gene in Schizosaccharomyces pombe is the first meiotic hot spot with an identified unique nucleotide sequence. We have purified 40,000-fold a heteromeric protein, containing polypeptides Mts1 (70 kD) and Mts2 (28 kD), that binds to the M26 site. Binding in vitro strictly...
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