Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of high‐ and low‐affinity receptors for C3a on the human mast cell line, HMC‐1

1 Apr 1996

Abstract excerpt

The proteolytic cleavage product of complement component 3, (C3a), is like C4a and C5a, is a potent anaphylatoxin and induces the production of inflammatory mediators in phagocytes. Notably, mast cells respond to C3a with the release of vasoactive substances, including histamine. We have examined the function and receptor binding of C3a in a human leukemic mast cell line, HMC-1. Similar to chemoattractant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Complement system in diseases
Share to Mast cells and histamine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8625964
DOI: 10.1002/eji.1830260405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of high‐ and low‐affinity receptors for C3a on the human mast cell line, HMC‐1PMID 8625964Read ↗

Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U‐937 cellsSemantic proximity Read ↗

Human Mast Cell Line HMC1 Expresses Functional Mas-Related G-Protein Coupled Receptor 2.Semantic proximity Read ↗

Recombinant human proteinase 3, the Wegener's autoantigen, expressed in HMC-1 cells is enzymatically active and recognized by c-ANCA.Semantic proximity Read ↗

Chimeric receptors of the human C3a receptor and C5a receptor (CD88).Semantic proximity Read ↗

Distinct and Shared Roles of β-Arrestin-1 and β-Arrestin-2 on the Regulation of C3a Receptor Signaling in Human Mast CellsSemantic proximity Read ↗

Cloning and functional expression of the canine anaphylatoxin C5a receptor. Evidence for high interspecies variability.Semantic proximity Read ↗

Structure-function studies of the C3a-receptor: C-terminal serine and threonine residues which influence receptor internalization and signaling.Semantic proximity Read ↗

The naturally occurring mutation Y197C does not affect the expression or signaling of the human histamine H3 receptor.Semantic proximity Read ↗

Human adenosine A(3) receptor leads to intracellular Ca(2+) mobilization but is insufficient to activate the signaling pathway via phosphoinositide 3-kinase gamma in mice.Semantic proximity Read ↗

Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure/function relationshipsSemantic proximity Read ↗

Interaction of C1q with its receptor on cultured cell lines induces an anti-proliferative responseSemantic proximity Read ↗

The high affinity calcium-binding site involved in protein C activation is outside the first epidermal growth factor homology domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.