Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific Signal Transduction of Constitutively Activating (D576G) and Inactivating (R476H) Mutants of Agonist-Stimulated Luteinizing Hormone Receptor in Eel.

International journal of molecular sciences - 23 May 2023

Choi Seung-Hee, Byambaragchaa Munkhzaya, Kim Dae-Jung, Lee Jong-Hyuk, Kang Myung-Hwa, Min Kwan-Sik

Abstract excerpt

We investigated the mechanism of signal transduction using inactivating (R476H) and activating (D576G) mutants of luteinizing hormone receptor (LHR) of eel at the conserved regions of intracellular loops II and III, respectively, naturally occurring in mammalian LHR. The expression of D576G and R476H mutants was approximately 58% and 59%, respectively, on the cell surface compared to those of eel LHR-wild type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chorionic Gonadotropin
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammals

Share to Mutation

Share to Receptors, LH

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 37298083
DOI: 10.3390/ijms24119133
PMCID: PMC10252337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific Signal Transduction of Constitutively Activating (D576G) and Inactivating (R476H) Mutants of Agonist-Stimulated Luteinizing Hormone Receptor in Eel.PMID 37298083Read ↗

Mutations in Conserved Regions of Eel Luteinizing Hormone Receptor Result in Constitutive Activation or InactivationSemantic proximity Read ↗

Characterization of constitutive activation and inactivation mutants in conserved regions of the eel luteinizing hormone receptorSemantic proximity Read ↗

<strong>Constitutive Activating and Inactivating Mutants of Eel Luteinizing Hormone Receptor</strong>Semantic proximity Read ↗

Constitutively Activating Mutants of Equine LH/CGR Constitutively Induce Signal Transduction and Inactivating Mutations Impair Biological Activity and Cell-Surface Receptor Loss In Vitro.Semantic proximity Read ↗

Constitutive Activation and Inactivation of Mutations Inducing Cell Surface Loss of Receptor and Impairing of Signal Transduction of Agonist-Stimulated Eel Follicle-Stimulating Hormone Receptor.Semantic proximity Read ↗

Structural requirements for mutational lutropin/choriogonadotropin receptor activation.Semantic proximity Read ↗

Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.Semantic proximity Read ↗

Transmembrane Regions V and VI of the Human Luteinizing Hormone Receptor Are Required for Constitutive Activation by a Mutation in the Third Intracellular LoopSemantic proximity Read ↗

A missense mutation in the second transmembrane segment of the luteinizing hormone receptor causes familial male-limited precocious puberty.Semantic proximity Read ↗

Characterization of Two Fly LGR (Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor) Proteins Homologous to Vertebrate Glycoprotein Hormone Receptors: Constitutive Activation of Wild-Type Fly LGR1 But Not LGR2 in Transfected Mammalian Cells**This study was supported by NIH Grant HD-23273. The GenBank submission number for fly LGR2 is AF274591.Semantic proximity Read ↗

Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor.Semantic proximity Read ↗

Differential Expression and Functional Characterization of Luteinizing Hormone Receptor Splice Variants in Human Luteal Cells: Implications for LuteolysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.