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Article

IGF-I, insulin and FGFs induce outgrowth of the limb buds of amelic mutant chick embryos.

Development (Cambridge, England) - 1 Apr 1996

Dealy C N, Kosher R A

Abstract excerpt

IGF-I, insulin, FGF-2 and FGF-4 have been implicated in the reciprocal interactions between the apical ectodermal ridge (AER) and underlying mesoderm required for outgrowth and patterning of the developing limb. To study further the roles of these growth factors in limb outgrowth, we have examined their effects on the in vitro morphogenesis of limb buds of the amelic mutant chick embryos wingless (wl) and...

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Source

Identifiers

PMID: 8620859
DOI: 10.1242/dev.122.4.1323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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IGF-I, insulin and FGFs induce outgrowth of the limb buds of amelic mutant chick embryos.PMID 8620859Read ↗

Function of BMPs in the apical ectoderm of the developing mouse limb.Semantic proximity Read ↗

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Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth.Semantic proximity Read ↗

The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation.Semantic proximity Read ↗

FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.Semantic proximity Read ↗

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.Semantic proximity Read ↗

Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.Semantic proximity Read ↗

Conserved mechanisms regulate outgrowth in zebrafish fins.Semantic proximity Read ↗

Functions of FGF signalling from the apical ectodermal ridge in limb development.Semantic proximity Read ↗

BMPs mediate lateral inhibition at successive stages in feather tract development.Semantic proximity Read ↗

Altered expression of the chicken homeobox-containing genes GHox-7 and GHox-8 in the limb buds of limbless mutant chick embryos.Semantic proximity Read ↗

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