Article
Pulmonary inflammatory, chemokine, and mutagenic responses in rats after subchronic inhalation of carbon black.
Toxicology and applied pharmacology - 1 Feb 1996
Driscoll K E, Carter J M, Howard B W, Hassenbein D G, Pepelko W, Baggs R B, Oberdörster G
Abstract excerpt
Chronic inhalation of carbon black can produce carcinomas in rat lungs. At present the mechanisms underlying the rat lung tumor response to carbon black are unknown, although a significant role for inflammation and cell proliferation has been postulated. To investigate the processes which may con...
Topics
- Administration, Inhalation
- Animals
- Base Sequence
- Body Burden
- Bronchoalveolar Lavage Fluid
- Carbon
- Chemokine CCL2
- Chemokine CXCL2
- Hypoxanthine Phosphoribosyltransferase
- Inflammation
- Lung
- Male
- Molecular Sequence Data
- Monokines
- Mutation