Article
STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes.
Particle and fibre toxicology - 17 Jul 2017
Duke Katherine S, Taylor-Just Alexia J, Ihrie Mark D, Shipkowski Kelly A, Thompson Elizabeth A, Dandley Erinn C, Parsons Gregory N, Bonner James C
Abstract excerpt
BACKGROUND: Pulmonary toxicity of multi-walled carbon nanotubes (MWCNTs) is influenced by physicochemical characteristics and genetic susceptibility. We hypothesized that contrasting rigidities of tangled (t) versus rod-like (r) MWCNTs would result in differing immunologic or fibrogenic responses in mice and that these responses would be exaggerated in transgenic mice lacking the signal transducer and activator...
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