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BCL7C suppresses ovarian cancer growth by inactivating mutant p53

23 Nov 2020

Abstract excerpt

B-cell CLL/lymphoma 7 protein family member C (BCL7C) located at chromosome 16p11.2 shares partial sequence homology with the other two family members, BCL7A and BCL7B. Its role in cancer remains completely unknown. Here, we report our finding of its tumor-suppressive role in ovarian cancer. Supporting this is that BCL7C is downregulated in human ovarian carcinomas, and its underexpression is associated with...

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PMID: 33306126
DOI: 10.1093/jmcb/mjaa065

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