Article
Mutational analysis of the p15 and p16 genes in acute leukaemias.
British journal of haematology - 1 Mar 1996
Sill H, Aguiar R C, Schmidt H, Hochhaus A, Goldman J M, Cross N C
Abstract excerpt
Recently the p16 and related p15 genes have been described as candidate tumour suppressors at chromosome 9p21. These genes have been found to be homozygously deleted at a high frequency in several types of solid tumours and also in acute lymphoid leukaemias. In order to determine whether these ge...
Topics
- Base Sequence
- Carrier Proteins
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Mutational Analysis
- Enzyme Inhibitors
- Exons
- Genes, Tumor Suppressor
- Hematopoietic Stem Cells
- Humans
- Leukemia
- Molecular Sequence Data
- Mutation
- Protein Kinase Inhibitors
- Tumor Cells, Cultured
- Tumor Suppressor Proteins