Mutation of p16, p21 or cyclin dependent kinase 4 is rare in acute lymphoblastic leukaemia.

doi:10.1046/j.1365-2141.1998.00974.x

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Article

Mutation of p16, p21 or cyclin dependent kinase 4 is rare in acute lymphoblastic leukaemia.

British journal of haematology - 1 Nov 1998

Qari M H, Khalil S H, Kambouris M, Meyer B F

Abstract excerpt

Homozygous deletion of the p16 tumour suppressor gene (at frequencies ranging from 14% to 29%) have been implicated in the pathogenesis of acute lymphoblastic leukaemia (ALL) by several studies. We investigated the prevalence of this deletion in a group of 46 Arab patients with common ALL. Deleti...

Topics

Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinases
Cyclins
DNA, Neoplasm
Enzyme Inhibitors
Gene Deletion
Genes, Tumor Suppressor
Genes, p16
Humans
Mutation
Neoplasm Proteins
Nucleic Acid Heteroduplexes
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed

Identifiers

PMID: 9827921
DOI: 10.1046/j.1365-2141.1998.00974.x

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9827921-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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