Article
Experimental transmission of Creutzfeldt-Jakob disease and related diseases to rodents.
Neurology - 1 Feb 1996
Tateishi J, Kitamoto T, Hoque M Z, Furukawa H
Abstract excerpt
Sporadic Creutzfeldt-Jakob disease (CJD) with 129M/M, and iatrogenic and familial CJD with E200K and M232R, showed similar clinicopathologic features, a synaptic type deposition of PrPCJD, and high transmission frequencies to mice. Sporadic patients with 129M/V or 129V/V, and mutation cases with...
Topics
- Adult
- Age of Onset
- Aged
- Animals
- Brain Tissue Transplantation
- Codon
- Creutzfeldt-Jakob Syndrome
- Cricetinae
- Electroencephalography
- Female
- Genotype
- Guinea Pigs
- Homozygote
- Humans
- Iatrogenic Disease
- Male
- Mice
- Middle Aged