Article
Inherited prion diseases and transmission to rodents.
Brain pathology (Zurich, Switzerland) - 1 Jan 1995
Tateishi J, Kitamoto T
Abstract excerpt
Clinico-pathological phenotypes of patients with prion diseases were compared with their PrP genotypes and transmission rate to mice. Sporadic and iatrogenic CJD patients without mutation and familial CJD patients with E200K showed uniform clinico-pathological features, synaptic-type deposition of PrPCJD and high rate of transmission of the disease to mice. GSS patients with P102L showed long duration of ataxia,...
Topics
- Animals
- Creutzfeldt-Jakob Syndrome
- Humans
- Immunohistochemistry
- Mice
- Mutation
- Point Mutation
- PrPSc Proteins
- Prion Diseases
- Prions