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Article

ERCC1/ERCC4 5'-endonuclease activity as a determinant of hypoxic cell radiosensitivity.

International journal of radiation biology - 1 Mar 1996

Murray D, Macann A, Hanson J, Rosenberg E

Abstract excerpt

In this study, the relationships between cellular oxygen enhancement ratios (OER) and nucleotide excision repair capability were examined using the UV20 mutant cell line (which has a defective ERCC1 gene). Using a clonogenic survival assay, the OER for the killing of wild-type AA8 cells was 3.2 +/- 0.1, whereas that for UV20 cells was only 2.35 +/- 0.05; the decreased OER of UV20 cells was the result of their...

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Source

Identifiers

PMID: 8613681
DOI: 10.1080/095530096145878

Genes

ERCC1
ERCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ERCC1/ERCC4 5'-endonuclease activity as a determinant of hypoxic cell radiosensitivity.PMID 8613681Read ↗

The importance of the ERCC1/ERCC4[XPF] complex for hypoxic-cell radioresistance does not appear to derive from its participation in the nucleotide excision repair pathway.Semantic proximity Read ↗

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Adaptive response to gamma radiation in mammalian cells proficient and deficient in components of nucleotide excision repair.Semantic proximity Read ↗

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