Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA.

doi:10.1038/ng1196-320

Article

Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA.

Nature genetics - 1 Nov 1996

Lo Ten Foe J R, Rooimans M A, Bosnoyan-Collins L, Alon N, Wijker M, Parker L, Lightfoot J, Carreau M, Callen D F, Savoia A, Cheng N C, van Berkel C G, Strunk M H, Gille J J, Pals G, Kruyt F A, Pronk J C, Arwert F, Buchwald M, Joenje H

Abstract excerpt

Fanconi anaemia (FA) is an autosomal recessive disorder characterized by a diversity of clinical symptoms including skeletal abnormalities, progressive bone marrow failure and a marked predisposition to cancer. FA cells exhibit chromosomal instability and hyper-responsiveness to the clastogenic a...

Topics

Amino Acid Sequence
Base Sequence
Blotting, Northern
Cell Cycle Proteins
Cells, Cultured
Cloning, Molecular
DNA, Complementary
DNA-Binding Proteins
Fanconi Anemia
Fanconi Anemia Complementation Group C Protein

Fanconi Anemia Complementation Group Proteins

Gene Expression

Genetic Complementation Test

Humans

Molecular Sequence Data

Mutation

Nuclear Proteins

Open Reading Frames

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