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Article

Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review.

Frontiers in immunology - 1 Jan 2020

Sharifinejad Niusha, Jamee Mahnaz, Zaki-Dizaji Majid, Lo Bernice, Shaghaghi Mohammadreza, Mohammadi Hamed, Jadidi-Niaragh Farhad, Shaghaghi Shiva, Yazdani Reza, Abolhassani Hassan, Aghamohammadi Asghar, Azizi Gholamreza

Abstract excerpt

Background: Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare combined immunodeficiency (CID) caused by recessive homozygous/compound heterozygous loss-of-function mutations in the ZAP70 gene. Patients with ZAP-70 deficiency present with a variety of clinical manifestations, particularly recurrent respiratory infections and cutaneous involvements. Therefore, a systematic review of ZAP-70...

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Identifiers

PMID: 32431715
DOI: 10.3389/fimmu.2020.00831
PMCID: PMC7214800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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