Article
Aged murine T-lymphocytes are more resistant to oxidative damage due to the predominance of the cells possessing the memory phenotype.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 1996
Lohmiller J J, Roellich K M, Toledano A, Rabinovitch P S, Wolf N S, Grossmann A
Abstract excerpt
Glutathione (GSH) is the most important cytosolic antioxidant. Since GSH levels are decreased with age, we hypothesized that T-lymphocytes from old mice would be more sensitive to oxidative stress. T-lymphocytes from young and old mice were exposed to hypoxanthine/xanthine oxidase, and lymphocyte viability, proliferation, GSH content, and calcium signaling were measured. Before exposure, proliferation of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.