Article
Design of multistable RNA molecules.
RNA (New York, N.Y.) - 1 Feb 2001
Flamm C, Hofacker I L, Maurer-Stroh S, Stadler P F, Zehl M
Abstract excerpt
We show that the problem of designing RNA sequences that can fold into multiple stable secondary structures can be transformed into a combinatorial optimization problem that can be solved by means of simple heuristics. Hence it is feasible to design RNA switches with prescribed structural alternatives. We discuss the theoretical background and present an efficient tool that allows the design of various types of...
Topics
- Base Pairing
- Base Sequence
- Computer Simulation
- Drug Design
- Hot Temperature
- Mathematics
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- Phylogeny
- RNA
- RNA Stability