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Article

Design of multistable RNA molecules.

RNA (New York, N.Y.) - 1 Feb 2001

Flamm C, Hofacker I L, Maurer-Stroh S, Stadler P F, Zehl M

Abstract excerpt

We show that the problem of designing RNA sequences that can fold into multiple stable secondary structures can be transformed into a combinatorial optimization problem that can be solved by means of simple heuristics. Hence it is feasible to design RNA switches with prescribed structural alternatives. We discuss the theoretical background and present an efficient tool that allows the design of various types of...

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Identifiers

PMID: 11233982
DOI: 10.1017/s1355838201000863
PMCID: PMC1370083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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