Article
Molecular basis for alpha-thalassemia associated with the structural mutant hemoglobin Suan-Dok (alpha 2 109leu----arg)
Blood - 15 Dec 1990
Weiss I, Cash F E, Coleman M B, Pressley A, Adams J G, Sanguansermsri T, Liebhaber S A, Steinberg M H
Abstract excerpt
Hemoglobin (Hb) Suan-Dok (alpha 109Arg) is a rare alpha-globin structural mutation that is linked to an alpha-thalassemia (alpha-thal) determinant. When inherited in trans to an alpha-thal-1 mutation (-), it results in Hb H disease associated with low levels (9%) of the Suan-Dok Hb. The nature of...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- DNA
- Electrophoresis, Cellulose Acetate
- Globins
- Hemoglobins, Abnormal
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Phenotype
- Plasmids
- Polymerase Chain Reaction
- Protein Biosynthesis
- RNA, Messenger
- Thalassemia