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Article

Molecular basis for alpha-thalassemia associated with the structural mutant hemoglobin Suan-Dok (alpha 2 109leu----arg)

Blood - 15 Dec 1990

Weiss I, Cash F E, Coleman M B, Pressley A, Adams J G, Sanguansermsri T, Liebhaber S A, Steinberg M H

Abstract excerpt

Hemoglobin (Hb) Suan-Dok (alpha 109Arg) is a rare alpha-globin structural mutation that is linked to an alpha-thalassemia (alpha-thal) determinant. When inherited in trans to an alpha-thal-1 mutation (-), it results in Hb H disease associated with low levels (9%) of the Suan-Dok Hb. The nature of the thalassemic defect associated with the alpha SD mutation has been investigated by structural and functional...

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PMID: 2265255

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Molecular basis for alpha-thalassemia associated with the structural mutant hemoglobin Suan-Dok (alpha 2 109leu----arg)PMID 2265255Read ↗

An alpha0-thalassemia-like mutation: Hb Suan-Dok [alpha109(G16)Leu-->Arg] carried by a recombinant -alpha(3.7) gene.Semantic proximity Read ↗

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The beta-globin C-->G mutation at 6 bp 3' to the termination codon causes beta-thalassaemia by decreasing the mRNA level.Semantic proximity Read ↗

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Analysis of mRNA from red cells of patients with thalassemia and hemoglobin variants.Semantic proximity Read ↗

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