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Article

Analysis of the determinants of neurotropism and neurotoxicity of HFV in transgenic mice.

Virology - 15 Feb 1996

Tschopp R R, Brandner S, Marino S, Bothe K, Horak I, Rethwilm A, Aguzzi A

Abstract excerpt

The Bel-1 protein of human foamy virus (HFV) is a transactivator acting on the U3 region of the long terminal repeat and on an internal promoter (IP) immediately upstream of the bel genes. An HFV transgene called delta gpe, containing both promoters and all bel genes, is expressed in the central nervous system and induces neurodegeneration in mice. To dissect the role of individual promoters and bel genes on...

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Identifiers

PMID: 8607263
DOI: 10.1006/viro.1996.0069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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