Comparative functional characterization of the feline foamy virus transactivator reveals its species specificity.

doi:10.1016/j.virol.2003.09.039

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Article

Comparative functional characterization of the feline foamy virus transactivator reveals its species specificity.

Virology - 5 Jan 2004

Bodem Jochen, Kang Yibin, Flügel Rolf M

Abstract excerpt

Foamy virus (FV) Bel1/Tas transactivators act as key regulators of gene expression and directly bind DNA Bel1 response elements (BREs) in both the internal (IP) and 5'LTR promoters. Here, we report the mapping and the virus species specificity of the nonhomologous feline foamy virus (FFV) BREs in both promoters. The data indicate that FFV Bel1 did not bind the primate FV IP.BRE and that primate FV Bel1 was not...

Topics

5' Untranslated Regions
Animals
Cats
Cells, Cultured
DNA-Binding Proteins
Gene Expression Regulation, Viral
Mutation
Primates
Promoter Regions, Genetic
Retroviridae Proteins
Species Specificity
Spumavirus
Terminal Repeat Sequences
Trans-Activators
Transcriptional Activation
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 14972532
DOI: 10.1016/j.virol.2003.09.039

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