Article
Effect of changes in the CD44 gene on tumour cell invasion in gliomas.
Neuropathology and applied neurobiology - 1 Oct 1997
Bouterfa H, Janka M, Meese E, Kerkau S, Roosen K, Tonn J C
Abstract excerpt
Cell adhesion is a critical factor in the multistep process of tumour invasion. CD44 is one of the cell surface adhesion molecules responsible for interaction with hyaluronic acid, a component of the CNS extracellular matrix. The aim of the present study was to demonstrate whether alterations in the CD44 gene might account for different invasive behaviour. EcoRI restriction analysis by Southern blot hybridization...
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