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Article

Histone-induced condensation of rat testis chromatin: testis-specific H1t versus somatic H1 variants.

Biochemical and biophysical research communications - 14 Jan 1994

De Lucia F, Faraone-Mennella M R, D'Erme M, Quesada P, Caiafa P, Farina B

Abstract excerpt

Due the likely role of H1 histone variants in inducing the formation of folded DNA filaments with different stabilities, the condensing capacity of the testis-specific H1t versus the somatic variants was tested. Circular dichroism analyses of rat testis H1-depleted oligonucleosomes (5-2kbp) revealed that H1t, which appears in germ cells during the meiotic prophase of mammalian spermatogenesis, exerts the lowest...

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PMID: 8292037
DOI: 10.1006/bbrc.1994.1005

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