Article
Epithelial colonies cultured from human explanted liver in subacute hepatic failure exhibit hepatocyte, biliary epithelial, and stem cell phenotypic markers.
Stem cells (Dayton, Ohio) - 1 Jan 2003
Selden Clare, Chalmers Sherri-Ann, Jones Catherine, Standish Richard, Quaglia Alberto, Rolando Nancy, Burroughs Andrew K, Rolles Keith, Dhillon Amar, Hodgson Humphrey J F
Abstract excerpt
The liver in subacute hepatic failure may become enriched for hepatic progenitor cells. Liver tissue from such a patient was collagenase digested and, from the nonparenchymal cell fraction, epithelioid colonies were developed. Albumin and alpha-1-antitrypsin (AAT) were secreted for greater than 120 days from these colonies. Reverse transcription-polymerase chain reaction showed expression of markers of both...
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