Article
Blind T-cell homeostasis in CD4-deficient mice.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Apr 1996
Adleman L M, Wofsy D
Abstract excerpt
Recently, it has been proposed that normal T-cell count is maintained by a homeostatic mechanism which is "blind" to the distinction between CD4+ T cells and CD8+ T cells. Interest in this blind homeostasis hypothesis (BHH) stems in part from its implications regarding the pathogenesis and treatment of HIV infection. In this report, BHH was tested in CD4-deficient mice. We found that as predicted by BHH, despite...
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