Article
A new highly polymorphic marker in the 5' untranslated region of HLA-F shows strong allelic association with haemochromatosis.
Human genetics - 1 Feb 1996
Raha-Chowdhury R, Bowen D J, Worwood M
Abstract excerpt
The 5' untranslated region of HLA-F contains a polypurine tract comprising repeats of tri- and hexa-nucleotide motifs. We have recently demonstrated that this polypurine tract is highly polymorphic by using the polymerase chain reaction. Here, we demonstrate that some of the alleles can be explained by a deletion of approximately 100 bp DNA and show that alleles of this novel, highly polymorphic locus are as...
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