A new highly polymorphic marker in the 5' untranslated region of HLA-F shows strong allelic association with haemochromatosis.

doi:10.1007/BF02265271

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Article

A new highly polymorphic marker in the 5' untranslated region of HLA-F shows strong allelic association with haemochromatosis.

Human genetics - 1 Feb 1996

Raha-Chowdhury R, Bowen D J, Worwood M

Abstract excerpt

The 5' untranslated region of HLA-F contains a polypurine tract comprising repeats of tri- and hexa-nucleotide motifs. We have recently demonstrated that this polypurine tract is highly polymorphic by using the polymerase chain reaction. Here, we demonstrate that some of the alleles can be explai...

Topics

Alleles
Chromosomes, Human, Pair 6
Female
Gene Frequency
Genes, MHC Class I
Genetic Markers
HLA Antigens
HLA-A3 Antigen
Hemochromatosis
Heterozygote
Histocompatibility Antigens Class I
Humans
Male
Minisatellite Repeats
Pedigree
Polymorphism, Restriction Fragment Length
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 8566959
DOI: 10.1007/BF02265271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8566959-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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