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Article

Duplication and loss of chromosome 21 in two children with Down syndrome and acute leukemia.

American journal of medical genetics - 6 Nov 1995

Rogan P K, Close P, Blouin J L, Seip J R, Gannutz L, Ladda R L, Antonarakis S E

Abstract excerpt

Acute leukemia in Down syndrome (DS) is often associated with additional changes in the number or structure of chromosome 21. We present two DS patients whose leukemic karyotypes were associated with changes in chromosome 21 ploidy. Patient 1 developed acute lymphocytic leukemia (type L1); disomy...

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Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 8588582
DOI: 10.1002/ajmg.1320590212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8588582-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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