Article
Broad spectrum beta-lactamases of Citrobacter diversus.
The Journal of antimicrobial chemotherapy - 1 Mar 1990
Oliva B, Segatore B, Amicosante G, Franceschini N, Oratore A, Bennett P M
Abstract excerpt
Citrobacter diversus NF85 produced a chromosomal beta-lactamase that was induced by a variety of beta-lactam antibiotics. Two major forms of the enzyme, with isoelectric points (pI's) of 5.7 and 6.2, were found in crude cell extracts. Derepressed mutants of NF85, generated by nitrosoguanidine treatment, displayed different levels of beta-lactamase expression to the parent strain and had different patterns of...
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