Article
A DLST genotype associated with reduced risk for Alzheimer's disease.
Neurology - 22 Apr 1999
Sheu K F, Brown A M, Kristal B S, Kalaria R N, Lilius L, Lannfelt L, Blass J P
Abstract excerpt
Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.