Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population.

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Article

Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population.

Annals of neurology - 1 Jan 1999

Sheu K F, Brown A M, Haroutunian V, Kristal B S, Thaler H, Lesser M, Kalaria R N, Relkin N R, Mohs R C, Lilius L, Lannfelt L, Blass J P

Abstract excerpt

The mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is deficient in Alzheimer's disease (AD). The DLST gene encodes the core, dihydrolipoyl succinyltransferase (DLST) component of KGDHC, and recent reports indicate an association between polymorphisms of DLST and AD in both white...

Topics

Acyltransferases
Age Factors
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Female
Genotype
Humans
Male
Polymorphism, Genetic
Restriction Mapping
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 9894876

Genes

DLST
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9894876-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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