Article
Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population.
Annals of neurology - 1 Jan 1999
Sheu K F, Brown A M, Haroutunian V, Kristal B S, Thaler H, Lesser M, Kalaria R N, Relkin N R, Mohs R C, Lilius L, Lannfelt L, Blass J P
Abstract excerpt
The mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is deficient in Alzheimer's disease (AD). The DLST gene encodes the core, dihydrolipoyl succinyltransferase (DLST) component of KGDHC, and recent reports indicate an association between polymorphisms of DLST and AD in both white and Japanese patients. We therefore examined the relationship between AD and the DLST and apolipoprotein E (APOE) genes...
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