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Article

Prion protein aggregation reverted by low temperature in transfected cells carrying a prion protein gene mutation.

The Journal of biological chemistry - 7 Nov 1997

Singh N, Zanusso G, Chen S G, Fujioka H, Richardson S, Gambetti P, Petersen R B

Abstract excerpt

Prion diseases are characterized by the conversion of the normal cellular prion protein (PrPC), a glycoprotein that is anchored to the cell membrane by a glycosylphosphatidylinositol moiety, into an isoform that is protease-resistant (PrPres) and pathogenic. In inherited prion diseases, mutations in the prion protein (PrPM) engender the conversion of PrPM into PrPres. We developed a cell model of...

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Identifiers

PMID: 9353306
DOI: 10.1074/jbc.272.45.28461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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