Article
The porcupine gene is required for wingless autoregulation in Drosophila.
Development (Cambridge, England) - 1 Dec 1995
Manoukian A S, Yoffe K B, Wilder E L, Perrimon N
Abstract excerpt
The Drosophila segment polarity gene wingless (wg) is required in the regulation of engrailed (en) expression and the determination of cell fates in neighboring cells. This paracrine wg activity also regulates transcription of wg itself, through a positive feedback loop including en activity. In addition, wg has a second, more direct autoregulatory requirement that is distinct from the en-dependent feedback loop....
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