Article
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.
The EMBO journal - 15 Dec 1993
van den Heuvel M, Harryman-Samos C, Klingensmith J, Perrimon N, Nusse R
Abstract excerpt
We have characterized the molecular nature of mutations in wingless (wg), a segment polarity gene acting during various stages of Drosophila development. Embryo-lethal alleles have undergone mutations in the protein-encoding domain of the gene, including deletions and point mutations of conserved...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Genes, Insect
- Genes, Regulator
- Molecular Sequence Data
- Mutation
- Precipitin Tests
- Proto-Oncogene Proteins
- RNA, Messenger
- Wnt1 Protein