Article
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.
The EMBO journal - 15 Dec 1993
van den Heuvel M, Harryman-Samos C, Klingensmith J, Perrimon N, Nusse R
Abstract excerpt
We have characterized the molecular nature of mutations in wingless (wg), a segment polarity gene acting during various stages of Drosophila development. Embryo-lethal alleles have undergone mutations in the protein-encoding domain of the gene, including deletions and point mutations of conserved residues. In a temperature sensitive mutation, a conserved cysteine residue is replaced by a serine. In embryo-viable...
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